Magnesium Glycinate and Sleep
A closer look at recent research on magnesium bisglycinate and sleep quality.
About the study
A 2025 randomized, double-blind, placebo-controlled trial investigated whether magnesium bisglycinate could support sleep quality in healthy adults reporting poor sleep.
The study enrolled 155 adults aged 18–65.
Participants received either 250 mg of elemental magnesium per day as magnesium bisglycinate or placebo.
After four weeks, the magnesium group showed a greater improvement on a standard sleep questionnaire than placebo.
The difference was statistically significant, but the effect size was small (Cohen's d = 0.2).
Key takeaway
Magnesium bisglycinate showed a modest improvement in self-reported sleep quality in adults reporting poor sleep.
The study does not show that every person will experience a sleep benefit, and it studied a higher elemental-magnesium dose than the amount listed for SUPRACALM.
What the research found
Important context
The trial used 250 mg of elemental magnesium per day.
SUPRACALM's label lists 100 mg of magnesium as magnesium glycinate.
SUPRACALM contains 100 mg of elemental magnesium per serving, from magnesium glycinate — less than the 250 mg used in this trial, so we don't claim the same result.
The result was modest.
The study itself described the improvement as modest, with a small effect size. That is exactly how we should present it.
Study details
What this means for SUPRACALM: Magnesium research helps explain why magnesium is included in the formula, but this study was performed on magnesium bisglycinate as an individual intervention, not on SUPRACALM. The study also used 250 mg of elemental magnesium, so it should not be presented as evidence that our 100 mg label amount produces the same result. Researched ingredients for a calmer evening.